Constant temperature shaking incubator for suspension cells Customized Bioreactor shaker
CO2 incubation shaker system coordinates substance production from basic research to pre-production. Chamber type temperature regulation advanced in accuracy with low risk of dew condensation and energy-saving.
●Incubating floating／suspended cells （like CHO cells）
●Efficient antibody production
●Transfection or incubation of HEK 293 cells
Up to 50L of culture bag available. For the production of vaccines and antibodies
For high density suspension cell culture, efficient shaking and gas exchange are extremely important. CBR-500S allows high density suspension cell culture by its rocking and active-gassing mechanisms. Up to 50L （working volume is 25L） culture bag is available, and the bag is tilted front and back by equal degrees to shaking medium gently.
●The motion of the bag （side view）
The bag is tilted front and back （degree is changeable）. Culture medium is shaking gently by rocking （sea-saw） mechanism of CBR-500S.
Concentration-controlled CO2 gas is flown forcibly and aseptically into the bag by an unique active-gassing mechanism.
●Hybridoma culture and antibody production comparison of bag and TC flask
The results which were obtained by culture bag with CO2 incubation shaker system, not only living cell density but also yield of antibody were higher than TC flask.
DO/pH monitoring and feedback system are available （options）
DO/pH monitoring and feedback system using PreSens non-invasive monitoring technology are available as options.
CBR-500S has a non-invasive/destructive DO/pH measuring system. A DO sensor spot are prefixed on the inner surface of the bag （CultiBag by Sartrius）, the oxgen concentration can therefore be measured in a non-destructive manner from outside, through the wall of the bag. pH is measured by a pH sensor spot in the same way.
*The position of each port of the bag which is shown in this figure is different from the product in order to simplify the description of this system.
TAITEC MG-1300M and CBR-500S DemoMovie
Temp. Control Accuracy
Rocking, degree changeable
5 to 50 r/min
atm. to 15.0%
50 to 500 ml/min, 1 line
DO/pH monitoring or feedback control(require Sartrius CultiBacg)